Module BISS2261: Clinical & Metabolic Biochemistry

Department: Biological and Biomedical Sciences (Biomedical Sciences) [Queen's Campus, Stockton]

BISS2261: Clinical & Metabolic Biochemistry

Prerequisites

• None.

Corequisites

• None.

Excluded Combination of Modules

• None.

Aims

• To develop a knowledge in metabolic and clinical biochemistry and to appreciate their dependant relationship.
• To develop a knowledge and understanding of the clinical laboratory and the uses of biochemical tests in the diagnosis of disease.
• To develop a knowledge and understanding of the biochemistry and hormonal control of selected metabolic pathways important for lipid, nucleic acids and protein metabolism and their links to human disease.

Content

• The clinical laboratory, accuracy and precision, quality control, coefficient of variation.
• Pancreatic and gastrointestinal hormones, glucose tolerance.
• Hormones acting at the nucleus and steroid hormones.
• Carbohydrate metabolism, Lipid metabolism, Amino acid metabolism, Nucleotide metabolism.
• Renin/angiotensin system.
• Renal function tests and fluid and electrolytes.
• Clinical enzymology.
• Blood gases.
• Acid-base homeostasis.
• Nutrition, total parental nutrition, malabsorption, Fe, Zn and Cu.
• Gastrointestinal disorders, muscle disorders.
• Therapeutic drug monitoring and toxicology.

Learning Outcomes

• On completion of this module students should have a knowledge and understanding of selected apects of metabolism and its regulation by hormones, and their role in homeostasis.
• They should be able to appreciate the biochemical differences between healthy and diseased states.
• Students should have a knowledge of the role of biochemical testing in the clinical laboratory.

• Students should be able to analyse and interpret clinical and experimental data as encountered in a clinical laboratory.
• Students should develop an understanding of the importance of quality control, precise and accurate measurement and reporting in clinical analysis.
• Students should be able to discuss the integration of metabolism.

• Students should be able to handle, interpret and present scientific data in a variety of ways.
• Students will be able to use the case study approach in the investigation of disease.

Modes of Teaching, Learning and Assessment and how these contribute to the learning outcomes of the module

• Lectures, Lab work, Practical reports, Unseen exam, Case study and Data handling.

Teaching Methods and Learning Hours

Summative Assessment

Formative Assessment:

Practical MCQ test

■ Attendance at all activities marked with this symbol will be monitored. Students who fail to attend these activities, or to complete the summative or formative assessment specified above, will be subject to the procedures defined in the University's General Regulation V, and may be required to leave the University