Module CHEM4481: ADVANCED RESEARCH CONCEPTS IN CHEMISTRY

Department: Chemistry

CHEM4481: ADVANCED RESEARCH CONCEPTS IN CHEMISTRY

Prerequisites

• Core Chemistry 3 (CHEM3012) AND two from [Inorganic Concepts and Applications (CHEM3097) OR Advanced Organic Chemistry (CHEM3117) OR Molecules and their Interactions (CHEM3137)].

Corequisites

• Core Chemistry 4 (CHEM4311).

Excluded Combination of Modules

• Bioactive Chemistry 4 (CHEM4211) OR Chemical Physics 4 (CHEM4411) OR Chemistry and Society (CHEM3061).

Aims

• To demonstrate contemporary research concepts in chemistry, chemical physics and chemistry at the interface with biology.

Content

• D - Metals in Medicine
• E - Recent developments and applications of solid-state NMR spectroscopy
• F - Research concepts in heterogeneous catalysis
• M - Enantioselective Catalyisis
• N - Organofluorine Chemistry
• O - Introduction to Agrochemistry
• U - Medicinal Chemistry II - From hit to pill
• V - Cold and Ultracold Molecules
• W - Optical Microscopy and Imaging
• [*Each student will follow six lecture courses. The choice will depend on modules taken at level-3 and student choice.

Learning Outcomes

• After attending the relevant lecture courses, students should be able to:
• D1 - Discuss the properties and reactions of metal complexes that make them suitable as therapeutic agents in the treatment of various diseases;
• E1 - Appreciate the role of solid-state NMR spectroscopy in the characterisation of solids and the information that can be extracted/obtained;
• E2 - Identify and explain the main interactions in solid-state NMR and their effect on NMR spectra;
• E5 - an introduction to dynamic nuclear polarisation (DNP) methods and applications, e.g., catalysis.
• F1 - Understand and appreciate current major research concepts in understanding how heterogeneous catalytic processes work (beyond Y2 surface science and Y3 catalysis courses);
• F2 - Appreciate the necessity for and methods available for understanding and measuring active sites and following catalytic processes in operando
• F3 - Understand the importance of both single crystal and nanostructured models for understanding heterogeneous catalytic mechanisms;
• F4 - Appreciate how fundamental scientific approaches are being used in real world applications through specific case studies of “hot reactions” relevant to current global challenges, e.g., solar energy harvesting or bio-refineries for chemicals production;
• M1 - understand the strategies available to obtain enantioenriched compounds
• M2 - discuss the thermodynamic and kinetic principles at the basis of enantioselective catalysis, particularly using metal complexes with chiral ligand or chiral counterions;
• N1 - Describe several methods for the introduction of fluorine atoms into organic systems;
• N2 - Discuss reactivity and mechanisms of fluoroalkenes, aromatics, heterocyclics and a mirror-image chemistry of related hydrocarbon systems;
• O1 - To Appreciate the societal importance of crop protection agents and other agrochemicals
• O2 - To Distinguish between intrinsic and biological effects of agrochemical inputs
• O3 - To Understand how an agrochemical can interact with its molecular target
• O4 - To be able to relate molecular structure to physicochemical parameters and downstream impact on compound efficacy
• O5 - To understand the steps of early stage agrochemical discovery - lead discovery and lead optimisation
• U1 - Understand the process of developing a successful "hit" from drug discovery into a final product;
• U2 - Understand the importance of solid-state forms and their characterisation for drug pharmacokinetics and patenting;
• V1 - Understand what is meant by the terms cold and ultracold and how the behaviour of molecules in these regimes of temperature differs from behaviour at higher temperatures;
• V2 - Describe the various experimental techniques employed to produce cold and ultracold molecules and know the current state of the art in experiment and theory;
• V3 - Appreciate the many applications of cold and ultracold molecules to contemporary problems in modern chemistry and physics;
• W1: understand the underlying physical principles behind optical microscopy and fundamental knowledge of key microscope components and their function and design progression;
• W2: Describe fluorescence microscopy and it’s application, including fluorescent dyes and their desired biocompatibility and physical properties; describe excitation sources and basic laser applications and important safety aspects;
• W3: Understand the confocal principle, including the achievable axial and lateral resolution with both single and multiphoton excitation and its application in life sciences;
• W4: Explain basic image acquisition and important cell culture techniques to compliment optical microscopy in life sciences, mounting techniques and application to real life applications.

Modes of Teaching, Learning and Assessment and how these contribute to the learning outcomes of the module

• Facts and new concepts are introduced in the lecture courses.
• Students' knowledge and understanding is tested by examination.
• Undergraduates are aided in the learning process by workshops where they attempt sample problems.

Teaching Methods and Learning Hours

Summative Assessment

Formative Assessment:

Workshop problems.

■ Attendance at all activities marked with this symbol will be monitored. Students who fail to attend these activities, or to complete the summative or formative assessment specified above, will be subject to the procedures defined in the University's General Regulation V, and may be required to leave the University